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Reserve · run the experiment

Run the experiment

Compare a healthy cell with a real documented patient under one shared drug, or switch to a single cell and pick the genotype yourself.

Avoid / high riskstrong oxidant stress

A sketch of how a clinician might reason about oxidant risk. The drugs and their risk tiers are real (CPIC; Youngster et al. 2010). How hard each one pushes this cell is illustrative — a qualitative stress level by risk tier, not a dose or a prediction. Not a clinical tool.

Drugs within the same risk tier are modeled at the same stress level — the model doesn't distinguish between them.

Threshold-window comparison. A healthy cell and Patient 3, a real documented severe G6PD-deficient patient, under the same oxidant. Healthy outcome: Strained — the reserve was drawn down hard, but it held. Patient outcome: Reserve exhausted — the cell is damaged past recovery and would be cleared.

Healthy cell — NADPH reservePatient 3 — NADPH reserve
oxidant onbaseline reservehemolysis threshold — below this, the reserve is failingthey separate here
Healthy cell
non-deficient reference
NADPH100%
Glutathione100%
Strained — the reserve was drawn down hard, but it held.
Patient 3
real documented case · Shimo et al. 2011
NADPH100%
Glutathione100%
Reserve exhausted — the cell is damaged past recovery and would be cleared.
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